In mid-June 2016, Cartoon Network released the first poster for the series, in which ten of the most popular aliens from the franchise were featured. The official Twitter feed of Cartoon Network PR confirmed a rebooted series that would return to following the adventures of Ben, Gwen, and Max Tennyson and feature new alien forms.

During their vacation, the Tennysons are attacked by various enemies, ranging from aliens such as intergalactic warlord Vilgax, bounty hunter duo Sixsix and Kraab, and Ectonurite high king Zs'skayr, criminals such as 11-year-old energy absorbing delinquent Kevin Levin, mad scientist Doctor Animo, and the mysterious paramilitary organization the Forever Knights, to supernatural entities such as interdimensional sorcerer Hex and his niece Charmcaster, and clown mastermind Zombozo and his Circus Freak Trio. On their first night camping in their grandfather's RV, nicknamed the Rust Bucket, Ben finds a mysterious watch-like alien device that attaches itself upon his wrist, giving him the ability to transform into several (initially ten but later more) alien life-forms, each with special abilities. The series centers on Ben Tennyson, a 10-year-old boy on a summer vacation road trip with his cousin Gwen and their grandfather Max, who is later revealed to be a member of a secret intergalactic organization called the Plumbers. On February 17, 2021, it was announced that three 44-minute specials based on the series would premiere in April 2021: titled Ben 10,010, Ben Gen 10 and Alien X-Tinction, serving as the series finale to the 2016 reboot and a crossover between the first four television series in the franchise. Worldwide, the franchise has grossed over $6 billion in retail sales. There is also a Ben 10 toy line manufactured by Bandai for the first four shows and Playmates Toys for the reboot. Spanning over 16 years, it is Cartoon Network's second longest-running franchise to date. It consists primarily of 5 television series and 5 films, the latter of which aired between August 2007 and October 2020.

The Ben 10 franchise has received widespread critical acclaim, winning 3 Emmy Awards. The Omnitrix initially contains ten aliens, although later on Ben obtains more species by adding and unlocking their DNA. Using the Omnitrix, Ben can transform into powerful aliens with various abilities. The series centers on a boy named Ben Tennyson who acquires the Omnitrix, an alien device resembling a wristwatch, which contains DNA of different alien species. Ben 10 is an American media franchise created by Man of Action Studios, produced by Cartoon Network Studios and owned by Warner Bros.

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